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Only three patients experienced transient cytokine release syndrome, with one patient also developing hypotension, briefly treated with dopamine

eNAMPT may also allow extracellular conversion of NAM to NMN, as eNAMPT is catalytically active 43

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People with GI conditions (such as chronic diarrhea, celiac disease, Crohn's disease, and ulcerative colitis) or who have had procedures like gastric bypass surgery that impair nutrient absorption are also at greater risk